Publications
Linking Single-Cell Transcriptomes with Secretion Using SEC-seq
Justin Langerman, Sevana Baghdasarian, Rene Yu-Hong Cheng, Richard G. James, Kathrin Plath & Dino Di Carlo
Nature Protocols, February 2025
Multi-reactive Hydrogel Nanovials for Temporal Control of Secretion Capture from Antibody-Secreting Cells
Michael Mellody, Yuta Nakagawa, Richard James and Dino Di Carlo
Lab on a Chip, January 2025
On the Compatibility of Single-Cell Microcarriers (Nanovials) with Microfluidic Impedance Cytometry
Cristian Brandi, Adele De Ninno, Filippo Ruggiero, Emanuele Limiti, Franca Abbruzzese, Marcella Trombetta, Alberto Rainer, Paolo Bisegna, and Federica Caselli.
Lab on a Chip, May 2024
Defining T cell receptor repertoires using nanovial-based binding and functional screening
Doyeon Koo, Zhiyuan Mao, Robert Dimatteo, Miyako Noguchi, Natalie Tsubamoto, Jami McLaughlin, Wendy Tran, Sohyung Lee, Donghui Cheng, Joseph de Rutte, Giselle Burton Sojo, Owen N. Witte & Dino Di Carlo
PNAS, March 2024
Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq
Shreya Udani, Justin Langerman, Doyeon Koo, Sevana Baghdasarian, Brian Cheng, Simran Kang, Citradewi Soemardy, Joseph de Rutte, Kathrin Plath & Dino Di Carlo
Nature Nanotechnology, December 2023
SEC-seq: Association of molecular signatures with antibody secretion in thousands of single human plasma cells
Rene Yu-Hong Cheng, Joseph de Rutte, Cade Ellis Ito, Andee R. Ott, Lucie Bosler, Wei-Ying Kuo, Jesse Liang, Brian E Hall, David J Rawlings, Dino Di Carlo, Richard G. James
Nature Communications, June 2023
Suspendable Hydrogel Nanovials for Massively Parallel Single-Cell Functional Analysis and Sorting
Joseph de Rutte, Robert Dimatteo, Maani M. Archang, Mark van Zee, Doyeon Koo, Sohyung Lee, Allison C. Sharrow, Patrick J. Krohl, Michael Mellody, Sheldon Zhu, James V. Eichenbaum, Monika Kizerwetter, Shreya Udani, Kyung Ha, Richard C. Willson, Andrea L. Bertozzi, Jamie B. Spangler, Robert Damoiseaux, and Dino Di Carlo
ACS Nano, March 2022
Scalable Fabrication and Use of 3D Structured Microparticles Spatially Functionalized with Biomolecules
Sohyung Lee, Joseph de Rutte, Robert Dimatteo, Doyeon Koo, and Dino Di Carlo
ACS Nano, November 2022